Telomerase Primer

[mage lang=”en|es|fr|en” source=”flickr”]telomerase primer[/mage]
what is the use of telomere and telomerase?

I know they both help solve problems that fills in gaps at the of 5′. But my question really is why is there gaps there? is it because the primer just leaves and the DNA polymerase doesnt give a damn about replacing RNA with DNA or what?

Well, sort of.

DNA polymerase has specific functions, it can replace RNA primers with DNA, but mechanistically it has to do it in a 5` to 3` direction.

So think about your 2 strands. 1 is a continuous polymerization, and has the 1 RNA primer at it’s 5` end. DNA polymerase has nothing upstream of that to bind to, thus resulting in missing DNA.

The other strand is the one that’s made up of Okazaki fragments (so that there are many short 5-3 replications due to the over all movement of DNA polymerase in the opposit direction of the DNA strand). All of those primers can get replaced except the very 5` one again, leaving a little missing DNA on both strands.