Telomerase Yeast

[mage lang=”en|es|fr|en” source=”flickr”]telomerase yeast[/mage]
What would happen of you replaced the yeast telomerase by the human equivalent in yeast cell?

The hint for that question (from my tutor) is: how does the cell know what to add to the ends?

This subject, no doubt, is a matter for interest for medical students and practioners and biologists, as well.
To describe this,…………”what would happen..if yeast telomerase is replaced by human equivalent”, would take a lot of space to write.

So, I am providing you with some interesting web-site results with “appropriate and on the topic” reviews and artcles that certainly deal with this topic refering to your question and also describe what may eventually happen.
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AN ARTICLE EXTRACTED -SUMMERY of a review

SUBJECT :Telomerase Catalytic Subunit Homologs from
Fission Yeast and Human
AUTHORS
Toru M. Nakamura, Gregg B. Morin, Karen B. Chapman,
Scott L. Weinrich, William H. Andrews, Joachim Lingner,*
Calvin B. Harley, Thomas R. Cech†
ABSTRACT
Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous genes from the fission yeast Schizosaccharomyces pombe and human are identified.
Disruption of the S. pombe gene resulted in telomere shortening and senescence, and expression of mRNA from the human gene correlated with telomerase activity in cell
lines. Sequence comparisons placed the telomerase proteins in the reverse transcriptase family but revealed hallmarks that distinguish them from retroviral and retrotransposon relatives.
Thus, the proposed telomerase catalytic subunits are phylogenetically conserved and represent a deep branch in the evolution of reverse transcriptases.
(taken from…. a PDF-file review by above mentioned authors)
http://www.uic.edu/labs/nakamura/pdf/2.pdf
READ more by clicking
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Please simply click to know some other details in the sites given below….

1. Humanized telomeres and an attempt to express a functional human …
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… of the yeast telomerase by the human enzyme may require additional human-specific components. … factors appear conserved between human and yeast cells. …
http://nar.oxfordjournals.org/cgi/content/full/32/6/1917

2. Humanized telomeres and an attempt to express a functional human …
… and an attempt to express a functional human telomerase in … of the yeast telomerase by the human enzyme may require additional human-specific components. …
http://nar.oxfordjournals.org/cgi/content/abstract/32/6/1917

3. “Telomerase catalytic subunit homologs from fission yeast and human”
“Telomerase Catalytic Subunit Homologs from Fission Yeast and Human” (1997) RELATED TOPICS … “Two Modes of Survival of Fission Yeast Without Telomerase” (1998) …
http://www.cs.cmu.edu/~lemur/science/DOCS/00368075.di002431.00p0147m.html

4. Telomerase Catalytic Subunit Homologs from Fission Yeast and Human …
… of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces … of Physical and Functional Anchor Site Interactions in Human Telomerase. …
http://www.sciencemag.org/cgi/content/short/277/5328/955

5. Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
… the fission yeast Schizosaccharomyces pombe and human are iden … and expression of mRNA from the human gene correlated with telomerase activity in cell …
http://www.uic.edu/labs/nakamura/pdf/2.pdf